"Transdifferentiation IV" portrays a human head in a reimagined anatomical illustration, vulnerable and exposed. At the temple, a pencil unwinds a cassette tape that wraps around the skull, enveloping it. Created for an exhibition featuring artists from the San Diego/Tijuana region collaborating with the chief investigating scientists from the Salk Institute in La Jolla, California, the brothers worked alongside a scientist researching cancer cells. Scientifically, transdifferentiation refers to reprogramming rogue T-cells from becoming cancerous to help regenerate tissues and organs. Inspired by this collaboration, the artwork and its title evoke themes of creation, transformation, and perpetual evolution.